Diagnosis of bladder cancer is often tentatively made via ultrasonographic imaging of the bladder but definitive diagnosis requires biopsy. Once a pet has been tentatively diagnosed with a bladder tumor by ultrasound, the next step often involves additional imaging to obtain a tissue sample for biopsy. This is often done using a small scope and camera (cystoscope) to directly visualize the mass and obtain image-guided biopsies in a minimally invasive manner. A diagnosis can also sometimes be obtained through ultrasound-guided catheterization, which is often cheaper and less invasive. Therefore, this latter method is often attempted first in the diagnostic work-up of suspected bladder tumor.
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